Use a sharp knife, serrated works best, to cut 4 ounces Bread into bite-sized pieces.
Place the bread cubes into a mixing bowl and toss with 2 tablespoons Olive Oil, 1 tablespoon Garlic powder, 2 teaspoons Onion powder and 1/2 teaspoon Oregano.
Arrange the cubed bread in a single layer on the air fryer tray or basket and place them into a preheated (400 degrees F) air fryer - air fry for 6 minutes until the bread cubes are golden and crispy.
Remove the tray from the air fryer and let it sit at room temperature for 20 to 30 minutes so that they are cool and crispy.